Disruptors of sestrin-MAPK interactions rejuvenate T cells and expand TCR specificity
Alessio Lanna, Clara D’Ambra, Federica Rinaldi, Luisa Chocarro, Manuel Delpero, Melania Capitani, Michael Karin
This paper develops DOS, a first-in-class disruptor of sestrin-MAPK complexes, which rejuvenates senescent T cells and expands TCR specificity by generating new T cell clones.
bioRxiv · May 17, 2024 · PreprintImmunology