Author

Manuel Llano

The University of Texas at El Paso

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Assay:metagenomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Denisse A. GutiérreziD· 2 shared Carlos A. ValenzuelaiD· 1 shared Carlos Valenzuela· 1 shared Chang-Soo SeongiD· 1 shared Sergio SaucedoiD· 1 shared Zachary S. Martinez· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 7 mutual co-author links

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2 shared papersMolecular Biology

Denisse A. GutiérrezORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

NF-κB-Driven HIV-1 Gene Expression in Human Cells Is Independent of Poly(ADP-ribose) polymerase-1 Function.

Denisse A. Gutiérrez, Manuel Llano

This study shows that PARP-1 is not required for NF-κB-driven HIV-1 gene expression in human CD4+ T cells, suggesting PARP-1 antagonism may reduce inflammation without affecting HIV reactivation.

bioRxiv · Mar 10, 2025 · PreprintMolecular Biology

Poly (ADP-ribose) polymerase-1 regulates HIV-1 replication in human CD4+ T cells

Zachary S. Martinez, Denisse A. Gutiérrez, Carlos A. Valenzuela, Chang-Soo Seong, Manuel Llano

This study shows PARP-1 deficiency or inhibition increases HIV-1 replication in human CD4+ T cells by enhancing viral infectivity and virion-associated Env levels.

bioRxiv · Jun 11, 2024 · PreprintMicrobiology

Schlafen14 Regulates Gene Expression Depending on Codon Usage

Carlos Valenzuela, Sergio Saucedo, Manuel Llano

This study shows that SLFN14 regulates gene expression based on codon usage, inhibiting HIV-1 replication by targeting rare codon-rich transcripts.

bioRxiv · Mar 19, 2023 · PreprintMolecular Biology