Author

Marco De Simone

Genentech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Assay:scRNA-seq· 3 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Approach:experimental assay· 1

Frequent Co-Authors

Giuseppe TestaiD· 2 shared Massimiliano PaganiiD· 2 shared Pietro Lo RisoiD· 2 shared Stefano PiccoloiD· 2 shared Abbas NaziriD· 1 shared Alejandro Lopez Tobon· 1 shared Alejandro ToboniD· 1 shared Aviv RegeviD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersDevelopmental Biology

Giuseppe TestaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Spatiotemporal profiling reveals the role of inflammatory niche in driving prostate cancer

Abbas Nazir, Hanchen Wang, Ziyu Lu, Jeffrey Lau, Frank Peale, Rajiv Jesudason, Kelli A. Connolly, Žaneta Andrusivová, Julia Lau, Sarah Gierke, Linna Peng, Sara Chan, Jian Jiang, Sandra Rost, Eric Lubeck, , Aviv Regev

This study uses single-cell and spatial profiling to show that inflammatory signals from macrophages and fibroblasts drive CD8 T cell exhaustion and resistance to immune checkpoint blockade in prostate cancer.

bioRxiv · Apr 22, 2026 · PreprintCancer Biology

Human cortical organoids expose a differential function of GSK3 on direct and indirect neurogenesis

Alejandro Tobon, Carlo Emanuele Villa, Cristina Cheroni, Sebastiano Trattaro, Nicolò Caporale, Paola Conforti, Raffaele Iennaco, Maria Lachgar-Ruiz, Marco Tullio Rigoli, Berta Marcó de la Cruz, Pietro Lo Riso, Erika Tenderini, Flavia Troglio, Marco de Simone, Isabel Liste, , Giuseppe Testa

This study uses human cortical organoids to show that GSK3 inhibition affects progenitor proliferation and tissue architecture, with specific impacts on outer radial glia and astrogenic lineage.

bioRxiv · Mar 4, 2019 · PreprintDevelopmental Biology

Single cell derived organoids capture the self-renewing subpopulations of metastatic ovarian cancer

Tania Velletri, Emanuele Carlo Villa, Michela Lupia, Pietro Lo Riso, Raffaele Luongo, Alejandro Lopez Tobon, Marco De Simone, Raoul J.P. Bonnal, Saverio Minucci, Stefano Piccolo, Nicoletta Colombo, Massimiliano Pagani, Ugo Cavallaro, Giuseppe Testa

This study develops a method to grow single-cell derived ovarian cancer organoids from patient ascites, which retain key subpopulations and features of the original metastasis not seen in 2D cultures.

bioRxiv · Nov 30, 2018 · PreprintCancer Biology