Ideal efficacy photoswitches for TRPC4/5 channels harness high potency for spatiotemporally-resolved control of TRPC function in live tissues
Markus Müller, Konstantin Niemeyer, Navin Kumar Ojha, Alin Sebastian Porav, Deivanayagabarathy Vinayagam, Nicole D. Urban, Fanny Büchau, Katharina Oleinikov, Mazen Makke, Claudia C. Bauer, Aidan V. Johnson, Stephen P. Muench, Frank Zufall, Dieter Bruns, Yvonne N. Schwarz, , Oliver Thorn‐Seshold
This paper develops and tests ideal efficacy photoswitch ligands for TRPC4/5 channels, enabling precise spatiotemporally-controlled modulation in live tissues.
Nature Chemical Biology · Jan 16, 2026Peer-reviewedCell Biology