Molecular BiologybioRxivPreprint
Mitochondrial cardiolipin metabolism controlled by tafazzin enables ferroptosis
Yvonne Wohlfarter, Judith Hagenbuchner, Utku Horzum…·Markus Andreas Keller
The paper shows that tafazzin deficiency in Barth Syndrome protects against ferroptosis by altering mitochondrial cardiolipin metabolism, affecting VDAC function and reducing ROS availability for ferroptosis.
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