Systematic analysis of genetic vulnerabilities caused by chromosome loss events in cancer
Yi Bei, Jessica Keane, Mason Lynch, Kurt M. Tamaru, Suyeon Lee, Lu Qiao, Pranav K. Kandikuppa, Gregory Gauthier-Coles, Wenqi Zhao, Klaske M. Schukken, Ines Forrest, Sarah L. Thompson, Stephanie K. Roessler, Alison Marie Taylor, Jason M. Sheltzer
This study identifies genetic vulnerabilities from chromosome loss events in cancer by analyzing CRISPR screening data and copy number profiles, revealing paralogous gene dependencies as therapeutic targets.
bioRxiv · Oct 28, 2026 · PreprintCancer Biology