Matthew Howell

Multi-omics Analysis Reveals Important Role for Microbial-derived Metabolites from Botryllus schlosseri in Metal Interactions

The paper investigates the interactions between metals, metabolites, and microbes in Botryllus schlosseri using multi-omics analysis.

An Updated Polygenic Index Repository: Expanded Phenotypes, New Cohorts, and Improved Causal Inference

The paper updates a polygenic index repository with more phenotypes, datasets, and improved causal inference methods, enhancing predictive performance and interpretability.

Activation of SEDS-PBP cell wall synthases by an essential regulator of bacterial division

This study identifies FzlA as a regulator linking FtsZ to PG synthesis during bacterial division, showing it activates and spatially orients division-specific PG synthases.

Repeat associated mechanisms of genome evolution and function revealed by the Mus caroli and Mus pahari genomes

The paper compares genome assemblies of Mus caroli and Mus pahari with Mus musculus and Rattus norvegicus to reveal lineage-specific evolutionary mechanisms, particularly repeat-associated processes.

Truncation and Motif Based Pan-Cancer Analysis Highlights Novel Tumor Suppressing Kinases.

The paper identifies novel tumor suppressor kinases using motif-based analysis and functional validation, highlighting the JNK pathway as tumor suppressive in gastric cancer.