Large-scale phenotyping and comparative genomics reveal genetic features of Listeria persistence in epithelial cells
Aurélie Lotoux, Matthieu Bertrand, Pierre-Emmanuel Douarre, Mounia Kortebi, Hélène Riveiro, Féderica Palma, Goran Lakisic, Edward M. Fox, Laurent Guillier, Anna Oevermann, Sophie Roussel, Hélène Bierne, Alessandro Pagliuso, Eliane Milohanic
This study identifies folate biosynthesis as critical for Listeria monocytogenes persistence in epithelial cells by regulating ActA levels and activity, revealing a metabolic pathway that enables vacuolar dormancy.
PLoS Pathogens · Apr 15, 2026Peer-reviewedMicrobiology