2-Guanidino-quinazoline promotes the readthrough of nonsense mutations underlying human genetic diseases
Laure Bidou, Olivier Bugaud, Goulven Merer, Matthieu Coupet, Isabelle Hatin, Egor Chirkin, Pauline François, Jean‐Christophe Cintrat, Olivier Namy
This study identifies 2-guanidino-quinazoline as a potent readthrough inducer for nonsense mutations, showing greater efficiency and broader sequence coverage than gentamicin.
bioRxiv · Nov 9, 2021 · PreprintMolecular Biology