Proteome-wide Mendelian randomization implicates TIMP2 as a putative causal protein for bone mineral density and fracture risk
Chen‐Yang Su, Maya Akerman, Masashi Hasebe, Douglas P. Kiel, Satoshi Yoshiji
This study uses proteome-wide Mendelian randomization to identify 18 circulating proteins causally linked to bone mineral density and fracture risk, with TIMP2 showing strong associations with lower BMD and increased fracture risk.
medRxiv · Mar 16, 2026 · PreprintGenetic & Genomic Medicine