Massively multiplex multimodal chemical screens at single-cell resolution
Kelvin Y. Chen, Romain Lopez, Basak Eraslan, Mayu Hata, Yusuke Takeshima, Kenichi Makino, Tatsuya Kibayashi, Kenji Ichiyama, Anne Biton, Jan-Christian Huetter, Anshul Bharat Kundaje, Jonathan K. Pritchard, Aviv Regev, Shimon Sakaguchi
The paper introduces a framework for multimodal chemical screens combining RNA, protein, and epigenomic readouts, revealing compound-specific mechanisms and off-target effects in T cells.
bioRxiv · May 27, 2026 · PreprintGenomics