Author

Melissa Chavez

Cedars-Sinai Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Developmental Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:trajectory inference· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Dmitriy SheyniD· 4 shared Julia Sheyn· 4 shared Minoo Bastani· 2 shared Wafa TawackoliiD· 2 shared Ahmet Engin PazarçevireniD· 1 shared Andrew I. SpitzeriD· 1 shared Angel Chen· 1 shared Angela PapalamprouiD· 1 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersCell Biology

Dmitriy SheynORCID

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4 papers

Recent·Most cited

Tendon-derived injectable bio-instructive gel augments tenogenic differentiation of iMSC-SCX cells and extracellular matrix remodeling

Ahmet Engin Pazarçeviren, Hyeongseop Keum, Léo‐Paul Tricou, Minoo Bastani, Melissa Chavez, Julia Sheyn, Gaia Dupont, Myung‐Seo Kim, Wafa Tawackoli, Benjamin R. Freedman, Dmitriy Sheyn

This study develops a porcine tendon-derived hydrogel to enhance tenogenic differentiation and extracellular matrix remodeling of iMSC-SCX cells in a rat tendon injury model.

bioRxiv · Sep 3, 2026 · PreprintCell Biology

Modulating Inflammation in Post-Traumatic Osteoarthritis using iPSC-derived Anti-inflammatory Macrophages

Nadia Mahmoudi, Lea Zila, Julia Sheyn, Namdev More, Melissa Chavez, Dean Roell, Rachel LevGur, Anoushka Prasad, Sarah Mohyeddinipour, Mia Orr, Minoo Bastani, Oksana Shelest, Sean Rajaee, Andrew I. Spitzer, Wafa Tawackoli, Dmitriy Sheyn

This study develops iPSC-derived anti-inflammatory macrophages to treat post-traumatic osteoarthritis, showing they reduce inflammation and improve joint outcomes in preclinical models.

bioRxiv · Aug 18, 2026 · PreprintCell Biology

A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain via Notochordal Cell Loss and Pain-inducing Nucleus Pulposus Cell Emergence

Giselle Kaneda, Jacob T. Wechsler, Melissa Chavez, Julia Sheyn, Karandeep Cheema, Chushu Shen, Dante Rigo De Righi, Lixia Wang, Yin‐Chen Hsu, Pablo Avalos, Yibin Xie, Debiao Li, Candace L. Floyd, Dmitriy Sheyn

This study develops a porcine model of intervertebral disc injury that mimics human discogenic pain through notochordal cell loss and nucleus pulposus cell emergence, validated by MRI, biobehavioral testing, and single-cell transcriptomics.

JOR Spine · Jul 9, 2026Peer-reviewedDevelopmental Biology

Single Cell Transcriptomics-informed Induced Pluripotent Stem Cells Differentiation to Tenogenic Lineage

Angela Papalamprou, Victoria Yu, Wensen Jiang, Julia Sheyn, Tina Stefanovic, Angel Chen, Chloe M. Castaneda, Melissa Chavez, Dmitriy Sheyn

This study differentiates human iPSCs to the syndetome stage using chemically defined media and small molecules informed by single-cell RNA-sequencing, revealing Wnt pathway involvement in off-target neural differentiation and improved syndetome induction with a WNT inhibitor.

eLife · Apr 24, 2026Peer-reviewedDevelopmental Biology