Ablation and Seed-driven Restoration of an Alpha-Satellite Devoid Human Centromere Reveals Size Homeostasis Mechanisms
Miao Lin, Shan Hua, Cody Naccarato, Zhao Zhang, Zhijie Liu, Fen Guo, Vanessa Horner, M. Anwar Iqbal, Archibald Perkins, Patrick J. Murphy, Bin Zhang
This study uses a genetically tractable neocentromere system to show that centromere formation involves a seed-driven expansion process and size homeostasis mechanisms.
bioRxiv · Aug 19, 2026 · PreprintCell Biology