The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi
Yannick Weyer, Sinead I. Schwabl, Xuechen Tang, Astha Purwar, Konstantin Adrian Siegmann, Angela Ruepp, Theresia Dunzendorfer-Matt, Michael A. Widerin, Veronika Niedrist, Noa J. M. Mutsters, Maria G. Tettamanti, Sabine Weys, Bettina Sarg, Leopold Kremser, Klaus Roman Liedl, , David Teis
This study identifies the Dsc ubiquitin ligase complex as a quality control mechanism at the Golgi that degrades orphaned proteins by assessing transmembrane domain hydrophobicity.
Nature Communications · Oct 26, 2024Peer-reviewedCell Biology