The phage stress test: a proving ground for genome language models in biological prediction
Emily M. Layton, Michael Bernauer, Laura D. Weinstock, Eric M. Small, Gina M. Geiselman, George D. Bachand, Jesse L. Cahill
This study evaluates a genome language model's ability to predict the effects of sequence changes in phages using experimental data, finding mixed success in distinguishing functional from nonfunctional mutations.
bioRxiv · Sep 24, 2026 · PreprintBioinformatics