SMURF2/USP7-mediated ubiquitination of KAP1 controls its SUMO E3 ligase activity and chromatin regulation
Sandy Boutros‐Suleiman, Kavya Nambiar, Pooja Anil Shah, Nilabja Roy Chowdhury, Meir Shamay, Gal Levy‐Cohen, Michael Blank
This study identifies SMURF2 and USP7 as regulators of KAP1 ubiquitination, showing that this dynamic cycle controls KAP1's SUMOylation activity and impacts chromatin structure and cancer progression.
bioRxiv · Aug 12, 2025 · PreprintMolecular Biology