Sequence-Specific Targeting of GC-Rich Gene Loci by Parallel Triplex-Forming Oligonucleotides Containing a Modified Nucleobase
Ruolin Ma, Michael Brazzill, Dylan Justice, Nicholas Buckham, Cen Chen, Shuichi Hoshika, Steven A. Benner, David A. Rusling
This paper demonstrates that Z-modified TFOs can repress endogenous gene expression by forming stable triplexes at GC-rich regulatory elements.
Nucleic Acids Research · Oct 13, 2026Peer-reviewedCell Biology