Michael DeGiorgio

A high resolution view of adaptive events

This study tracks mutations during coadaptation between E. coli and plasmid pBR322 using duplex sequencing, revealing clonal interference and chromosomal variant emergence as key adaptive events.

Demographic and immune-based selection shifts before and after European contact inferred from 50 ancient and modern exomes from the Northwest Coast of North America

The paper analyzes 50 ancient and modern exomes from the Northwest Coast of North America to infer demographic and immune-based selection shifts before and after European contact, finding a population size reduction and selection pressure changes on immune genes.

Detecting recent selective sweeps while controlling for mutation rate and background selection

The paper improves the detection of recent selective sweeps by incorporating fixed differences and modeling background selection, enhancing power and localization accuracy.