Retrotransposon Activity in Chronic Lymphocytic Leukemia: Associations with RNA Splicing and TP53 Dysfunction
Anastasiya Volakhava, Šárka Pavlová, Lenka Radová, Kristýna Taušová, Hana Svozilová, Marcela Ženatová, Michael Doubek, Ilgar Mamedov, Šárka Pospı́šilová, Karla Plevová
This study investigates the relationship between TP53 dysfunction, LINE-1 retrotransposon activity, and transcriptomic changes in CLL, finding that retrotransposons influence RNA splicing rather than causing DNA damage.
bioRxiv · Jul 17, 2026 · PreprintCancer Biology