Author

Michael E Weale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:variant effect prediction· 2 Approach:Bayesian inference· 1 Research Focus:benchmarking· 1 Assay:DNA methylation· 1 Assay:GWAS summary statistics· 1 Organism:human· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Jo Knight· 2 shared Michael R Barnes· 2 shared Sarah A Gagliano· 2 shared Cathryn M Lewis· 1 shared Moira Verbelen· 1 shared Reena Ravji· 1 shared

Activity by Year

2013-2016 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 7 mutual co-author links

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2 shared papersBioinformatics

Jo Knight

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cost-effectiveness of pharmacogenetic-guided treatment: are we there yet?

Moira Verbelen, Michael E Weale, Cathryn M Lewis

This study reviews economic evaluations of pharmacogenetic-guided treatments and finds that cost-effectiveness improves significantly if genetic testing is free.

bioRxiv · Jul 23, 2016Genetics

Circumstantial Evidence? Comparison of Statistical Learning Methods using Functional Annotations for Prioritizing Risk Variants

Sarah A Gagliano, Reena Ravji, Michael R Barnes, Michael E Weale, Jo Knight

This paper compares statistical learning methods using functional annotations to prioritize risk variants in genome-wide association studies, finding similar predictive accuracies across methods but no significant improvement over existing approaches.

Scientific Reports · Aug 24, 2015Peer-reviewedBioinformatics

A Bayesian Method to Incorporate Hundreds of Functional Characteristics with Association Evidence to Improve Variant Prioritization

Sarah A Gagliano, Michael R Barnes, Michael E Weale, Jo Knight

This paper introduces a Bayesian method that integrates functional genomic data with GWAS results to prioritize causal SNPs, showing improved identification of novel hits in psoriasis GWAS.

bioRxiv · Dec 4, 2013Bioinformatics