An Isogenic iPSC Model of LMNA p.R482W Recapitulates Adipocyte Dysfunction in Familial Partial Lipodystrophy Type 2
Aluet Borrego Alvarez, Will Oliver Wasielewski, McKinlee R.S. Gobble, Michael Grupe, Lina M. Ali, William Buchser, Lauren Boggs-Bailey, Dustin Baldridge, Jessica N. Maung, Akira Nishii, Ormond A. MacDougald, Elif A. Oral, Stephen I. Stone
This paper develops an isogenic iPSC model of FPLD2 carrying the LMNA p.R482W variant, showing adipocyte dysfunction including insulin resistance and metabolic impairment.
bioRxiv · Nov 2, 2026 · PreprintGenomics