Interferon Regulatory Factor 5 (IRF5) Interacts with the Translation Initiation Complex and Promotes mRNA Translation During the Integrated Stress Response to Amino Acid Deprivation
James D. Warner, Mandi Wiley, Ying-Y Wu, Feng Wen, Michael Kinter, Akiko Yanagiya, Kandice L. Tessneer, Patrick M. Gaffney
This study shows IRF5 promotes mRNA translation of ATF4 during amino acid deprivation by interacting with the translation initiation complex without eIF4E.
bioRxiv · Jul 15, 2017 · PreprintBiochemistry