Michael Klemba

The role of Plasmodium falciparum acyl-coenzyme A synthetase 10 in fatty acid acquisition and lipid synthesis

This study investigates the role of Plasmodium falciparum ACS10 in fatty acid acquisition and lipid synthesis during the asexual blood stage, showing its necessity for incorporating specific fatty acids into parasite lipids.

Development of semisynthetic blasticidin S analogs with potent and fast-killing anti-malarial activity

This study develops semisynthetic blasticidin S analogs with higher anti-malarial potency and selectivity than the natural product.

Defining the minimal enzymatic requirements for fatty acid scavenging from lysophosphatidylcholine by erythrocytic Plasmodium falciparum

This study identifies PARE as a third enzyme required for Plasmodium falciparum to scavenge fatty acids from lysophosphatidylcholine, showing that its loss combined with XL2/XLH4 deficiency impairs parasite survival.