development & morphogenesis

SPACE-Tag Enables High-Throughput Spatial Chromatin Profiling With CUT&Tag

The paper introduces SPACE-Tag, a spatial CUT&Tag method for chromatin profiling, and applies it to the mouse brain to reveal age-related chromatin and transcriptome changes.

Magnetic organelle gene clusters enable bacterial growth and ATP homeostasis under oxidizing conditions

This study shows that gene clusters for magnetite formation in bacteria confer resistance to hydrogen peroxide, supporting an early origin of magnetotactic bacteria before Earth's oxygenation.

Broad Cognitive and Motivational Enhancement through M4-Selective Muscarinic Modulation

This study evaluates a M4-selective PAM in nonhuman primates, showing broad cognitive and motivational improvements without adverse side effects.

A hierarchical Bayesian model for dynamic phenotypes in multi-environment trials with genotype by environment interaction

The paper develops a hierarchical Bayesian model to analyze dynamic phenotypes in multi-environment trials, quantifying genotype, environment, and G x E effects on growth parameters.

Neurons entrain and shape an intrinsic arteriole rhythm that distributes blood across the cortical mantle

The paper shows neurons entrain an intrinsic arteriole rhythm, shaping blood distribution and vascular responses through frequency-dependent mechanisms.

Evolutionary dynamics of the pan-centromere architecture in oaks

The paper analyzes centromere evolution in oaks, showing lineage-specific expansion of QuCEN146 satellite drives turnover, while LTR-rich centromeres show low polymorphism due to suppressed recombination.

Starve, stress, and mate: Activation of the CCAAT-Binding complex overrides sterility of mating-type heterozygous Candida albicans

The paper identifies the CCAAT-binding complex (CBC) as a key regulator that overrides genetic sterility in Candida albicans by integrating environmental stress signals to enable mating.

Deprivation of dietary fiber promotes low-grade neuroinflammation and anxiety-like behavior in mice

This study shows that depriving mice of fermentable dietary fiber leads to low-grade neuroinflammation and anxiety-like behavior, which are reversed by fiber supplementation.

An expansive internal chemosensory system in the insect abdomen implicates Gustatory Receptors in diverse aspects of interoception

This study identifies an internal chemosensory system in Drosophila melanogaster's abdomen using Gustatory Receptors, revealing new roles in interoception beyond traditional feeding behaviors.

Distinct lifespan trajectories of cortical intrinsic timescales and neural oscillations

The paper examines lifespan changes in neural temporal dynamics using resting-state MEG data, finding distinct trajectories for cortical intrinsic timescales and alpha oscillations.

Multi-scale biophysical modeling of fungal colony growth

This paper develops a multiscale model of fungal colony growth combining discrete hyphal mechanics with a stochastic traveling-wave surrogate to simulate growth efficiently and reveal macroscopic patterns.

Growing a Root from Its Genome : Emergent Tissue Layers and Zones in a GPU-Native Simulation of the Arabidopsis Root Tip

This paper simulates Arabidopsis root tip development from a genome, showing emergent cell identities and zones without pre-defined structures, but with limitations in niche maintenance and regeneration.

Invasion analysis for structured populations: analytical principles and numerical workflows

The paper develops a framework for analyzing invasion in structured populations using analytical and numerical methods to determine invasion success across different ecological scenarios.

Historical contingency is revealed by trade-offs upon sequential adaptation to different infection routes

This study shows that past adaptation to systemic infection affects the speed and mechanism of adaptation to oral infection in Drosophila, with sex-specific outcomes and trade-offs.

A multipotent mouse distal airway secretory cell population that contributes to both airway and alveolar regeneration

This study identifies a multipotent secretory cell population in mouse distal airways that contributes to both airway and alveolar regeneration after injury.

Regenerative epithelial spike cells instruct immune niche homeostasis in zebrafish fin epidermis

The paper identifies a novel epithelial cell type in zebrafish fins, spike cells, and shows their role in maintaining immune cell niche homeostasis through interactions with mpeg1+ immune cells.

Persistent hippocampal traces of lifelong spatial memory

The paper shows that mice retain spatial memory in the hippocampus after long absences, with neural patterns persisting despite changes in individual neuron activity.

Active eye modeling: a tool for estimating retinal image quality across the visual field in everyday life

This paper introduces active eye modeling to estimate retinal image quality across the visual field during everyday activities, finding that near work under dim lighting increases peripheral blur.

Mutually Repressive Transcription Factors Drive Intestinal Maturation for Weaning

This study identifies BLIMP1 and CASZ1 as mutually repressive transcription factors that regulate intestinal enterocyte maturation during weaning and corticosteroid-induced maturation.

Compositional computations in the primate frontal cortex

The paper investigates how neural circuits in the primate frontal cortex support compositional generalization by separating computations into spatial and temporal components and identifying biases when these components are misaligned.

Responses of Muscle Volume, Strength, and Motor Unit Properties to Bed Rest and Retraining in Young Males and Females

This study examines sex differences in muscle volume, strength, and motor unit properties during bed rest and retraining in young males and females, finding no sex differences in strength loss but greater MU firing rate reduction in females.

Traveling waves in attention networks inherit the rhythms of sensory systems

The paper investigates whether traveling waves in attention networks reflect top-down attention signals or are a byproduct of sustained attention, finding they align with the intrinsic rhythms of engaged sensory systems.

Light-dependent conversion of body color change pattern during zebrafish development

This study shows that light exposure during rearing induces a developmental switch in zebrafish body color response to light, independent of pineal photoreceptors.

Infant Sensory Over-Responsivity: Relations to Early Life Adversity, Emerging Behavioral Problems, and Sensory Functional Connectivity

This study identifies prenatal adversity and neonatal brain connectivity as predictors of infant sensory over-responsivity, which links to later behavioral problems.

Genome-wide chromatin accessibility during early embryogenesis in a generalist cichlid fish

This study maps genome-wide chromatin accessibility in A. calliptera embryos across three stages, revealing dynamic changes in regulatory elements and transcription factor activity during early development.

Human lymphatic organoids reconstruct convergent developmental routes to functional lymphatic vessels

This study generates human lymphatic organoids from pluripotent stem cells using two mesodermal routes, showing they form functional vascular networks and support immune interactions.

Ferroptosis of selective progenitor cell types during embryogenesis ensures proper organ morphogenesis

This study identifies ferroptosis in embryonic lung and kidney progenitor cells, showing its role in organ morphogenesis through genetic manipulation of Gpx4.

Sexual interactions and local selection shape reproductive gene diversity and divergence

The paper identifies genes under co-evolutionary selection in Drosophila melanogaster by analyzing nucleotide diversity and divergence patterns, finding links to sperm competition and mating behaviors.

Genetic Variation in Photosynthetic Maintenance and Post-Chill Recovery for Early Season Maize Plantings

This study evaluates genetic variation in maize's response to chilling stress and recovery, identifying heritable traits linked to cold resilience.

Dynamic allocation of MurJ coordinates bacterial growth and division

The paper shows that MurJ, a Lipid II flippase, dynamically coordinates bacterial growth and division by transiently capturing at division sites during septal synthesis.