PYM1 limits non-canonical Exon Junction Complex occupancy in a gene architecture dependent manner to tune mRNA expression
Manu Sanjeev, Lauren A. Woodward, Michael L. Schiff, Robert D. Patton, Sean Myers, Debadrita Paul, Ralf A. Bundschuh, Guramrit Singh
This study shows PYM1 regulates EJC occupancy in a gene architecture-dependent manner, affecting mRNA stability and decay, and is exploited by flaviviruses to alter host mRNA regulation.
Nature Communications · Aug 30, 2025Peer-reviewedMolecular Biology