Cell type-specific meQTL extends melanoma GWAS annotation beyond eQTL and informs melanocyte gene regulatory mechanisms
Tongwu Zhang, Jiyeon Choi, Ramile Dilshat, Berglind Osk Einarsdottir, Michael A. Kovacs, Mai Xu, Michael Malasky, Salma Chowdhury, Kristine M. Jones, David Timothy Bishop, Alisa M. Goldstein, Mark Martin Iles, Maria Teresa Landi, Matthew H. Law, Jianxin Shi, , Kevin M. Brown
The paper identifies cell-type-specific meQTLs in melanocytes and melanomas, enhancing GWAS annotation and revealing regulatory mechanisms involving IRF4.
The American Journal of Human Genetics · Jul 21, 2021Peer-reviewedGenetics