Author

Michael Pressler

Columbia University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Ajna UzuniiD· 2 shared Christian A. GordilloiD· 2 shared David W Harle· 2 shared Elham AziziiD· 2 shared Joshua FulleriD· 2 shared Kirubel BelayiD· 2 shared Lingting ShiiD· 2 shared Markus Y. MaparaiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Ajna UzuniORCID

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2 papers

Recent·Most cited

A Donor T-Cell Receptor Structural Signature Determines Alloreactive Potential and Predicts Acute Graft-Versus-Host Disease

Ximi Kevin Wang, Ajna Uzuni, Lingting Shi, David W Harle, Rodney Macedo, Michael Pressler, Christian A. Gordillo, Kirubel Belay, Shami Chakrabarti, Joshua Fuller, Elizabeth Olson Hexner, Alison Wakoff Loren, David L. Porter, Markus Y. Mapara, Megan Sykes, , Ran Reshef

The paper identifies a T-cell receptor structural signature that predicts acute GVHD risk by analyzing alloreactive clonotypes and introduces a metric to quantify clonal dominance.

bioRxiv · Jul 11, 2026 · PreprintImmunology

Spatiotemporal Single-Cell Analysis Reveals T Cell Clonal Dynamics and Phenotypic Plasticity in Human Graft-versus-Host Disease

Lingting Shi, Ajna Uzuni, Ximi Kevin Wang, Michael Pressler, David W Harle, Shami Chakrabarti, Rodney Macedo, Kirubel Belay, Christian A. Gordillo, Erik Raps, Jia Yi Zhang, Achille Nazaret, Joy Linyue Fan, Yinuo Jin, Xin Shen, , Ran Reshef

This study uses spatiotemporal single-cell analysis to track T cell clonal dynamics and phenotypic plasticity in GVHD, revealing links between TCR features, clonal expansion, and disease severity.

bioRxiv · May 24, 2025 · PreprintSystems Biology