Direct 3D isolation in gelatin methacryloyl microbeads versus conventional 2D isolation and culture: a trade-off between mesenchymal stromal cell purity and niche-associated transcriptional profiles
Nali Hussein, Cornelius Miller, Yvonne Roger, Letizia Venturini, Michael Stadler, Marco Haertlé, Antonina V. Lavrentieva, Nadin Haase, Sophia Rudorf, Andrea Hoffmann, Dominik Egger
This study compares 3D GelMA microbeads with 2D culture for MSC isolation, finding 2D yields purer MSCs while 3D retains niche-associated transcriptional profiles.
bioRxiv · Oct 13, 2026 · PreprintCell Biology