Toward Clinical Implementation of Polygenic Scores for Substance Use Disorders: A Multi-Ancestry Study
Dongbing Lai, Michael Zhang, Tae-Hwi Linus Schwantes-An, Marcus R. Breese, Karen Chartier, Christina M. Sheerin, Martin Henry Plawecki, Changyong Guo, Yao‐Ying Ma, Zhiping P. Pang, Howard J. Edenberg, Tatiana Foroud, Yunlong Liu
The paper develops and validates polygenic scores for substance use disorders across multiple ancestries, finding clinically relevant performance in European and Latinx populations but not in African populations.
medRxiv · Jul 6, 2026 · PreprintGenetic & Genomic Medicine