Lipophilic compounds restore wt function of neurodevelopmental-associated KCNQ3 mutations.
Michaela A. Edmond, Andy Hinojo-Perez, Mekedlawit Efrem, Yi-Chun Lin, Iqra Shams, Sébastien Hayoz, Alicia de la Cruz, Marta E. Perez Rodriguez, Maykelis Díaz, Derek M. Dykxhoorn, Yun Lyna Luo, René Barro-Soria
The paper investigates how two KCNQ3 mutations impair channel function and shows that polyunsaturated fatty acids can restore wild-type function in these mutations.
Communications Biology · Sep 19, 2024Peer-reviewedBiophysics