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Frequency-Dependent Structural Responses of Amyloid-β Fibrils to Terahertz Pulses: A Nonequilibrium Molecular Dynamics Study

This study uses nonequilibrium molecular dynamics to show frequency-dependent structural changes in amyloid fibrils under terahertz pulses, identifying two electric-field thresholds for disruption.

Maximum Likelihood Localization Maps

This paper introduces a non-iterative method to create molecular probability maps from single-molecule localization data, preserving positional likelihood without coordinate-based rendering.

Temperature-dependent Fano resonance in Microtubules and Tubulin investigated with Spontaneous Raman Spectroscopy

The paper measures Raman spectra of microtubules and tubulin at various temperatures to investigate Fano resonance asymmetry in molecular bond vibrations.

Quantum Entanglement as a Physical Determinant of Genomic Instability in TP53

The paper explores whether quantum entanglement, measured via von Neumann Entropy, influences TP53 mutation patterns, finding elevated entropy at known mutational hotspots but cautioning about limited validation.

Lysenin Induced Membrane Curvature on Erythrocytes and Nanoporous Mica Free Standing Membranes

This study shows lysenin pores induce membrane curvature into rigid dome-like structures, suggesting beta-PFTs alter host cell membranes beyond pore formation.

Distributed Network Sensing as an Escape Strategy

The paper shows that slime mould networks can detect and escape harmful environments through reconfiguration, depending on their size and connectivity.

Highly conserved talin isoforms encode distinct mechanical responses and ligand-binding capabilities

This study examines how sequence differences between talin-1 and talin-2 affect their mechanical responses and ligand-binding capabilities, revealing distinct mechanical behaviors and new interaction sites in talin-2.

Amyloid stability and condensate material properties independently govern the hnRNPA2 condensate to fibril transition

This study shows that amyloid structure and condensate stability independently influence the hnRNPA2 condensate-to-fibril transition, revealing a structural framework for this process.

Multi-scale biophysical modeling of fungal colony growth

This paper develops a multiscale model of fungal colony growth combining discrete hyphal mechanics with a stochastic traveling-wave surrogate to simulate growth efficiently and reveal macroscopic patterns.

Structural Basis of Second-Generation HIV-1 Maturation Inhibitor Activity by Magic Angle Spinning NMR

This study uses MAS NMR to determine the binding mode of HRF-4467, a second-generation HIV-1 maturation inhibitor, in the CA-SP1-NC11 complex with IP6, revealing its mechanism of action and resistance profile.

Organised streaming of cerebrospinal fluid in the human third ventricle

The paper investigates how pressure pulses from cardiac and respiratory activity generate CSF motion in the human third ventricle and shows how increasing Reynolds number affects residual streaming.

siRNA/mRNA payload of lipid nanoparticles quantified using fluorescence microscopy and correlation spectroscopy

The paper quantifies mRNA and siRNA payload in lipid nanoparticles using fluorescence microscopy and FCS, showing size-dependent payload and coencapsulation dynamics.

Opposing Roles of Cholesterol and Cholesterol Sulfate in Proton Transfer and Diffusion at Membrane Interfaces

This study shows cholesterol and cholesterol sulfate have opposing effects on proton transfer and diffusion at membrane interfaces, with cholesterol promoting local transfer and inhibiting long-range diffusion, while cholesterol sulfate does the opposite.

FUSION PORE CLOSURE DETERMINES SUBQUANTAL KISS-AND-RUN SEROTONIN RELEASE FROM FULLY LOADED DENSE-CORE VESICLES

This study shows that subquantal serotonin release during kiss-and-run exocytosis is due to fusion-pore closure, not vesicle depletion.

hAM-pe soluble extract increases human keratinocyte HaCaT cell-line mobility in scratch assays

The paper shows that hAM-pe extract accelerates wound closure in HaCaT cells by enhancing cellular motion persistence rather than individual speed.

TRPP Ion Channels Function in the π-Conformation Rather Than the α-Conformation

This study uses molecular dynamics simulations to show that the π-conformation of PKD2 supports ion conduction, challenging the previous model that the α-conformation is the conductive state.

Lipidic α-synuclein fibrils catalyze the formation of pathological mature fibrils

This study shows lipidic α-synuclein fibrils catalyze the formation of mature fibrils through a heterogeneous nucleation mechanism, lowering the energy barrier and following Ostwald's Rule of Stages.

The binding landscape of Ras/effector interactions provides insights on Ras switching and oncogenesis

This study maps the Ras/Nore1A binding landscape under different states and mutations, revealing how oncogenic changes alter interaction dynamics and provide insights for inhibitor design.

Growth-driven mechanical buckling as a mechanism of age-related tortuosity in human cerebral arteries

This study models age-related tortuosity in human cerebral arteries as growth-driven mechanical buckling under spatial constraints, supported by imaging data from MRI.

A topoietic model of collective morphogenesis and compartmentalization

The paper introduces topoiesis, a mechanism where diffusion and geometry drive collective morphogenesis and survival in Xenopus embryos under stress.