Functional Proteomics of ABC Importers Reveal Synchronization of Mechanisms, Cellular Abundances, and Counterintuitive Stoichiometries
Hiba Qasem Abdullah, Nurit Livnat Levanon, Michal Perach, Moti Grupper, Tamar Ziv, Oded Lewinson
The paper develops a proteomic approach to study E. coli ABC importers, revealing abundance variations, inverse correlations between substrate-binding protein affinities and permease interactions, and counterintuitive stoichiometries.
bioRxiv · Feb 23, 2025 · PreprintBiochemistry