Suzetrigine (VX-548) exhibits activity-dependent effects on human dorsal root ganglion neurons
Megan L. Uhelski, Mandee K. Schaub, Felipe Espinosa, Mario Heles, Nicolás Andrés Cortés Mejía, Yan Li, Claudio Esteves Tatsui, Laurence D. Rhines, Robert Y. North, Christopher A Alvarez-Breckenridge, Geoffrey A. Funk, Peter Horton, Anna M. Cervantes, Joseph B. Lesnak, Michele Curalto, , Patrick M. Dougherty
This study examines suzetrigine's effects on human dorsal root ganglion neurons, showing it suppresses spontaneous pain-related discharges but requires longer exposure to affect evoked pain.
bioRxiv · Apr 9, 2025 · PreprintNeuroscience