Elucidation of remdesivir cytotoxicity pathways through genome-wide CRISPR-Cas9 screening and transcriptomics
Ersin Akıncı, Minsun Cha, Lin Lin, Grace Hui Ting Yeo, Marisa C. Hamilton, Callie J. Donahue, Heysol C. Bermudez-Cabrera, Larissa Cardoso Zanetti, Maggie Chen, Sammy A. Barkal, Benyapa Khowpinitchai, Nam Ky Chu, Minja Velimirovic, Rikita Jodhani, James D. Fife, , Richard I. Sherwood
This study identifies genetic pathways involved in remdesivir cytotoxicity using CRISPR-Cas9 screening and transcriptomics, finding that SLC29A3 and AK2 are key factors in toxicity and efficacy.
bioRxiv · Aug 27, 2020 · PreprintGenetics