Lin Lin

Uncertainty-Guided Decision-Making in Bumble Bees

This study shows bumble bees make decisions based on uncertainty, adjusting choices to avoid errors and seeking information when uncertain, suggesting ancient neural mechanisms for uncertainty monitoring.

MATR3 is essential for oocyte growth and maturation quality through a dual molecular mechanism

This study identifies MATR3's role in oocyte growth and maturation through transcriptional regulation and paracrine signaling, showing its importance in fertility and potential as a therapeutic target for OMA.

Calcium directs actin assembly via allosteric activation of formin INF2

This study identifies Ca2+-CaM as a direct activator of INF2, linking calcium signals to actin assembly and mitochondrial fission through an allosteric mechanism.

Essential function reflected in the phylodynamics of a multigene family: the pir genes of malaria parasites

This study investigates the evolutionary dynamics and essential function of pir genes in malaria parasites, identifying pirC1 as critical for blood stage growth and suggesting a role in host cell interaction or nutrient uptake.

A near-complete lamprey genome illuminates ancestral vertebrate innovations

This paper presents a near-complete lamprey genome assembly, revealing gene family expansions and regulatory elements linked to vertebrate innovations.

Generative Modelling of Oncogene-carrying Extrachromosomal Circular DNA Biogenesis and Dynamics in Cells

The paper develops a method to generate oncogene-carrying ecDNAs in human cells and studies their expression and stability under different conditions.

Complex feline disease mapping using a dense genotyping array

This study uses a dense genotyping array to identify genome-wide associations for three complex feline diseases in a multi-breed cohort of cats.

R-type voltage-gated Ca2+ channels mediate A-type K+ current regulation of synaptic input in hippocampal dendrites

This study identifies Cav2.3 as a regulator of Kv4.2-mediated K+ current in hippocampal neurons, showing its role in synaptic input regulation and dendritic excitability.

Paradoxical relationships between active transport and global protein distributions in neurons

The paper quantifies Kv4.2 ion channel transport in neurons, revealing higher axonal transport despite dendritic expression, and explains this with mathematical models of intracellular trafficking.

High resolution discovery of regulatory DNA with synthetic wild-type and ablated genome constructs

This study introduces STARR-scan, a computational method that identifies transcription factor motifs in synthetic DNA constructs linked to enhancer activity, revealing new regulators of the APOBEC-3B gene.

Elucidation of remdesivir cytotoxicity pathways through genome-wide CRISPR-Cas9 screening and transcriptomics

This study identifies genetic pathways involved in remdesivir cytotoxicity using CRISPR-Cas9 screening and transcriptomics, finding that SLC29A3 and AK2 are key factors in toxicity and efficacy.

Illuminating microbial metabolic activities in the dark deep ocean with metaproteomics

This study uses metaproteomics to analyze microbial metabolic activity in the deep ocean, revealing key functional groups and metabolic processes involved in carbon cycling.