Nuclear retention and RNA editing safeguard self-tolerance to immunogenic intron lariats
Keonyong Lee, Jayoung Ku, Soo Young Park, Tria Asri Widowati, Moonhyeon Jeon, Namwook Kim, Hyukjun Chung, Min Ji Kim, Da Sol Kim, Ha Yeon Kim, Hyewon Chung, Woo Dae Jang, Han Suk Ryu, Yoosik Kim
The paper investigates how intron lariats, especially those with transposable elements, trigger immune responses in cancer cells and shows that RNA editing and DBR1 depletion can be used to enhance anti-tumor effects.
bioRxiv · Nov 10, 2026 · PreprintMolecular Biology