Pathogenic strains of a gut commensal drive systemic platelet activation and thromboinflammation in lupus nephritis
Abhimanyu Amarnani, Cristobal F. Rivera, MacIntosh Cornwell, Tyler Weinstein, Susan R.S. Gottesman, Cynthia A. Loomis, Zakia Azad, Andy Chao Hsuan Lee, Joshua Prasad, Betsy Jo Barnes, Mingyang Yi, Nimat Ullah, Nicolas Gisch, Kelly V. Ruggles, Bhama Ramkhelawon, Gregg J. Silverman
This study shows that pathogenic Ruminococcus gnavus strains in the gut drive platelet activation and thromboinflammation in lupus nephritis, with antibodies against its lipoglycan as a potential biomarker.
bioRxiv · Jun 20, 2025 · PreprintImmunology