Dissecting the TMEM132A-EGFR Dependency to Unlock Translational Therapeutic Opportunities for Pan-Solid Tumor
Yaru Fu, Qiqi Ni, Junhao Wang, Mingyu Wu, Cheng Zhang, Jixian Wang, Jiayi Qian, Wentong Fang, Gong Li, Jing Yao, Dan Zhang, Li Gong, Fei Zhao, Ninghong Song, 何远桥, , Xijuan Liu
This paper identifies TMEM132A as a pan-cancer target that stabilizes EGFR and drives lipid synthesis, and develops a nanobody to inhibit this interaction, showing antitumor activity in resistant models.
bioRxiv · Sep 1, 2026 · PreprintCancer Biology