The Deacetylases HDAC1 and HDAC2 Safeguard BCR-ABL-positive Cells from Replication Stress-Induced Apoptosis via the Nuclear to Mitochondrial p73-NOXA Axis
Al‐Hassan M. Mustafa, Miriam Pons, Nisintha Mahendrarajah, Maren Wiegerling, Jörg Hartkamp, Markus Christmann, Markus Philipp Radsak, Günter Schneider, Matthias Wirth, Oliver Holger Krämer
This study shows HDAC1 and HDAC2 protect BCR-ABL-positive CML cells from replication stress-induced apoptosis via the p73-NOXA axis.
bioRxiv · Dec 16, 2025 · PreprintCancer Biology