Patient-derived organoids reveal hypoxia-driven plasticity and therapeutic vulnerabilities in pheochromocytomas and paragangliomas
Xiaojing Wang, Maite Calucho, Cynthia M. Estrada-Zuniga, Misbah Noureen, Hector Gonzalez‐Cantu, Samantha Mossuto, Jonathan N. Levi, Bethany N. Landry, Qianjin Guo, Kailee A. Rutherford, Zi-Ming Cheng, Andreanne Sannajust, Sapna Raghunathan, Sanskriti Balaji, Viviane Nascimento Da Conceicao, , Patricia L. M. Dahia
This study uses patient-derived organoids to model pheochromocytomas and paragangliomas, revealing hypoxia-driven plasticity and therapeutic vulnerabilities, including responses to abemaciclib.
bioRxiv · Aug 22, 2025 · PreprintCancer Biology