Rational mRNA Structure -guided Attenuation Enables Embryo-safe in-ovo NDV Vaccination and Protection
Tamir Tuller, Zohar Zafrir, Dana Goldenberg, Avner Finger, Yevgeny Khinitz, Modi Roopin
The paper develops an embryo-safe NDV vaccine by using structure-aware synonymous mutations to modulate RNA folding, achieving high hatchability and protection against NDV challenge.
bioRxiv · Oct 1, 2026 · PreprintSynthetic Biology