Mukilan Mohan

An approach for single-amino-acid resolution epitope mapping by kinetic affinity screening of antibody drugs against biosensor on-chip library of deep mutationally-scanned target variants

This paper introduces a method to map epitopes at the single amino acid level by screening antibody drugs against a mutationally-scanned target protein library on a biosensor chip, identifying critical residues for binding.

Novel sensor-integrated proteome on chip (SPOC) platform with thousands of folded proteins on a 1.5 sq-cm biosensor chip to enable high-throughput real-time label-free screening for kinetic analysis.

The paper introduces a high-throughput proteomic platform called SPOC that enables real-time label-free screening of protein interactions with kinetic analysis capabilities.

An approach to produce thousands of single-chain antibody variants on a SPR biosensor chip for measuring target binding kinetics and for deep characterization of antibody paratopes

This paper demonstrates a high-throughput method to produce and characterize thousands of single-chain antibodies on an SPR biosensor chip, providing detailed kinetic data to support antibody discovery and AI pipelines.