Prediction of incident coronary artery disease in individuals with zero coronary artery calcium using a novel multi-ancestry, label-free polygenic risk score framework
Giordano Bottà, Muriel Rossi, Jen Kintzle, Paolo Di Domenico
This paper develops a label-free polygenic risk score framework to identify residual CAD risk in individuals with zero coronary artery calcium, finding higher risk in top PRS groups despite normal imaging.
medRxiv · Mar 4, 2026 · PreprintGenetic & Genomic Medicine