Neoepitope-specific vaccination of a patient with diffuse midline glioma targeting H3K27M induces polyclonal B and T cell responses across diverse HLA alleles
T. Boschert, K. Kromer, T. Lerner, K. Lindner, G. Haltenhof, C. L. Tan, K. Jahne, I. Poschke, L. Bunse, N. Grassl, I. Mildenberger, K. Sahm, M. Platten, J. M. Lindner, E. W. Green
This study describes a patient with diffuse midline glioma who achieved remission after vaccination with an H3K27M peptide vaccine, showing robust T and B cell responses across diverse HLA alleles.
bioRxiv · Apr 28, 2023 · PreprintCancer Biology