NAD+ biosynthesis as a collateral lethality target for precision oncology
F. L. Muller, P. Deng, N. Satani, Y.-H. Lin, N. Hammoudi, G. Mohapatra, J. M. Asara, R. A. DePinho
The paper identifies NMNAT2 as a collateral lethality target in cancers with NMNAT1 deletions, showing selective toxicity in vitro and tumor eradication in vivo.
bioRxiv · Dec 13, 2022 · PreprintCancer Biology