Cell shape, and not 2D migration, predicts ECM-driven 3D cell invasion in breast cancer
J. P. Baskaran, A. Weldy, J. Guarin, G. Munoz, M. Kotlick, N. Subbiah, A. L. Wishart, Y. Peng, M. A. Miller, L. Cowen, M. Oudin
This paper develops a pipeline to predict ECM protein effects on breast cancer invasion by analyzing cell shape and migration metrics, finding that cell shape better predicts 3D invasion than 2D migration.
bioRxiv · Dec 31, 2019Bioengineering