Author

Naoki Sekiguchi

University of Tsukuba

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Akiyoshi FukamizuiD· 1 shared Hiroaki DaitokuiD· 1 shared Kaori MotomuraiD· 1 shared Koichiro KakoiD· 1 shared N. IkedaiD· 1 shared Natsuki OdateiD· 1 shared Rikuto KondoiD· 1 shared Ryuhei TsukamotoiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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9 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

Akiyoshi FukamizuORCID

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1 paper

Recent·Most cited

Secreted protein methyltransferase METTL9 catalyzes Nπ-histidine methylation of extracellular plasma proteins

N. Ikeda, Hiroaki Daitoku, Natsuki Odate, Naoki Sekiguchi, Ryuhei Tsukamoto, Rikuto Kondo, Song‐iee Han, Kaori Motomura, Koichiro Kako, Akiyoshi Fukamizu

The paper identifies METTL9 as the first secreted methyltransferase that catalyzes Nπ-histidine methylation of extracellular plasma proteins, establishing histidine methylation as the second extracellular post-translational modification.

bioRxiv · Dec 23, 2025 · PreprintBiochemistry