Nose-to-Knee Transplantation for Osteochondral Regeneration: A Proof-of-Concept Study in Sheep Employing Ceramic-Hydrogel Osteochondral Grafts
Philipp Fisch, Seyed‐Iman Roohani‐Esfahani, Simone Ponta, Siyi Chen, Nathan Alibert, David Fercher, Karina Klein, Brigitte von Rechenberg, Marcy Zenobi‐Wong, Salim Darwiche, Hala Zreiqat, Anna Puiggalí‐Jou
This study develops autologous osteochondral grafts in sheep using nasal chondrocytes and 3D-printed scaffolds, showing mechanical maturity but limited integration due to implant sinking.
bioRxiv · Oct 12, 2026 · PreprintBioengineering