Single RNA molecule resolution spatial imaging of immunotherapy response in triple negative breast tumors harboring tertiary lymphoid structures
Richard H. Mebane, Teia Noel, Nathan Ing, Kenneth H. Gouin, Aagam S. Shah, David Zitser, Andrew Martinez, Gaorav P. Gupta, Alice Y. Ho, Heather L. McArthur, Stephen Lawrence Shiao, Simon Knott
The paper uses single RNA molecule resolution imaging to analyze immunotherapy response in triple negative breast tumors with tertiary lymphoid structures, identifying two tumor types based on immune infiltration and their differential responses to pembrolizumab and radiation therapy.
bioRxiv · Mar 19, 2024 · PreprintGenomics