KCa3.1 Drives Pro-Fibrotic Activation and Represents a Novel Therapeutic Target in Aortic Stenosis
Molly Whitfield, Saadia Aslam, João Goncalves De Sousa, Daniel Taveira, Catherine McMullan, Mathuscha Ratnasingham, Gill Elliiott, S M Duffy, Neil Craig, Stefan Alexander Veizades, Stephanie Sellers, Hiwa Sherzad, Metesh Acharya, Giovanni Mariscalco, Gerry Patrick McCann, , Katy Morgan Roach
This study shows KCa3.1 channels drive fibrosis in aortic stenosis by promoting myofibroblast contraction and collagen production, and inhibition with senicapoc reduces these effects.
bioRxiv · May 4, 2026 · PreprintCell Biology